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Let's face it. You picked up that first copy of Doc Savage and looked at the cover...you said "Cool", "Neato", or "Far Out" (depending on your age)...but you were sold when you read that blurb on the back. That's what made you rush home to read your first Doc Savage. And we've interviewed* the man that wrote most of those one-paragraph classics....
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Most Doc fans know the force behind Kenneth Robeson was Lester Dent. Mr. Dent didn't write every Doc story, but he could have. The man was a Writing Machine. He had a secret to writing so quickly, a secret he shares with us.
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Agents that are injected directly into the penis exert their relaxant effect directly on the corpora cavernosal smooth muscle. They can be used as single agents or in combination. The most commonly used agents include PGE1, papaverine, and phentolamine. The dose and most effective combination of these agents must be determined for each patient. These medications can be obtained commercially as Caverject (PGE1) or can be formulated according to the physician's request by compounding pharmacies. Patients can be supplied with vials of a single agent or a combination of agents mixed in a single vial. Patients must be instructed in the proper technique for administration. A single intraurethral agent, PGE1, which has been formulated into a small suppository, is commercially available as MUSE. This agent was available prior to the introduction of sildenafil and is still used by a select group of men.
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Mechanical Genital trauma or surgery; Peyronie's disease; congenital abnormalities Fibrous penile plaques or chordae None
CYP4503A4 inhibitors (eg, erythromycin, ketoconazole, itraconazole, indinavir, ritonavir) may significantly increase levels; potentiates hypotensive effects of nitrates and alpha-blockers (with exception of tamsulosin when given as 0.4 mg qd); concurrent alcohol consumption may increase orthostatic hypotension risk
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Table 4. Patient demographics. Ranges and percentages are provided in parentheses.
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